Postdoc position in Development of in vitro skin model including sensory perception 100%, Basel, fixed-term

Postdoc position in Development of in vitro skin model including sensory perception

100%, Basel, fixed-term

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For a collaboration project between the Bio Engineering Laboratory (Department of Biosystems Science and Engineering
of ETH Zurich in Basel) and Novartis AG, Basel, Switzerland, we are seeking a highly motivated and enthusiastic
Postdoc. You will have a unique opportunity to collaborate across scientific and organizational boundaries with a focus
on developing powerful advanced skin models to study barrier function and itching that have the potential of
therapeutic breakthroughs for patients.

Project background

Leveraging cutting-edge advanced cellular models, and bioengineering and microfluidic approaches, the project is aimed
at developing skin models that include sensory perception for understanding immunological skin diseases and for
applications in drug discovery. Current ex vivo skin models, although widely used in pharmaceutical and cosmetic
research, fall short of assessing - in real-time - itch-inducing and barrier-compromising conditions. Emerging models,
based on primary keratinocytes and induced-pluripotent-stem-cell (iPSC), can better replicate physiological and disease
conditions. However, such models need to be adapted for pharmaceutical research and target identification.

Job description

- In this collaborative effort, you will devise an in vitro 3D human skin model to investigate barrier function under
homeostatic conditions and in response to inflammatory stimuli
- By combining state-of-the-art engineering and microfluidic approaches with new cellular models, you will develop new
skin models that include sensory perception and will find applications in fundamental science and drug testing
- You will have a dual role in setting up and culturing the 3D skin models and optimizing sensor technology (e.g. TEER
and TEWL) to enable a robust assessment of skin barrier functionality
- In addition, itch perception will be studied by the integration of iPSC-derived sensory neurons

Profile

- Considering the dual aspects of this position, we are looking for a candidate with a strong background in biology
and engineering (e.g., bioengineering, biotechnology, or related fields) with a solid knowledge of molecular biology
and cell culturing, preferably in microphysiological systems
- Important experience includes primary cell culturing, work with advanced in vitro models, epithelial/endothelial
barrier characterization, and iPSC differentiation; skills in optical microscopy, sensor development and integration,
as well as in electrophysiology are a plus
- Academic excellence, a professional attitude, and a self-driven nature are expected
- Strong communication skills, fluency in English, and a proactive mindset are essential for thriving in this
collaborative, international environment

The position is fully funded for initially 2 years, an extension to up to 4 years is possible. The starting date is
flexible but must be before 06-2026.

Workplace

Workplace

We offer

- Your job with impact: Become part of ETH Zurich, which not only supports your professional development, but also
actively contributes to positive change in society
- You can expect numerous benefits, such as public transport season tickets and car sharing, a wide range of sports
offered by the ASVZ, childcare and attractive pension benefits

chevron_right Working, teaching and research at ETH Zurich

We value diversity and sustainability

In line with our values, ETH Zurich encourages an inclusive culture. We promote equality of opportunity, value
diversity and nurture a working and learning environment in which the rights and dignity of all our staff and students
are respected. Visit our Equal Opportunities and Diversity website to find out how we ensure a fair and open
environment that allows everyone to grow and flourish. Sustainability is a core value for us – we are consistently
working towards a climate-neutral future.

Curious? So are we.

We look forward to receiving your online application by February 15th 2026.

A complete application package includes

- A short and specific motivation statement for the advertised position (max. 1 page)
- Complete academic transcripts
- An up-to-date CV
- At least two reference letters (or contact details of referees).

Please note that we exclusively accept applications submitted through our online application portal. Applications
submitted via e-mail or postal services or incomplete application packages will not be considered.

Further information about the Bio Engineering Laboratory can be found on our website. For more information on the
position, please contact exclusively via e-mail: mario.modena@bsse.ethz.ch .

About ETH Zürich

ETH Zurich is one of the world’s leading universities specialising in science and technology. We are renowned for our
excellent education, cutting-edge fundamental research and direct transfer of new knowledge into society. Over 30,000
people from more than 120 countries find our university to be a place that promotes independent thinking and an
environment that inspires excellence. Located in the heart of Europe, yet forging connections all over the world, we
work together to develop solutions for the global challenges of today and tomorrow.

About ETH Zürich

ETH Zurich is one of the world’s leading universities specialising in science and technology. We are renowned for our
excellent education, cutting-edge fundamental research and direct transfer of new knowledge into society. Over 30,000
people from more than 120 countries find our university to be a place that promotes independent thinking and an
environment that inspires excellence. Located in the heart of Europe, yet forging connections all over the world, we
work together to develop solutions for the global challenges of today and tomorrow.